Dystrophin (DMD) Antikörper

Antigen: Dystrophin (DMD)

Synonyme: DMD, MGC155049, Dmd, MGC83347, DKFZp459C1629, dmd, MGC79631, DKFZp468A1620, Dp71, cb664, zfDYS, im:6911785, zgc:110165, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, mdx, pke, Dp427, DXSmh7, DXSmh9, RATDMD, DNADMD1, CG17750, CG31175, CG7240, CG7243, CG7344, DLP, DLP1, DLP186, DLP2, DLP3, DmDLP, DmDYS, Dp205, GI3046716, dmDp186, DmelCG34157, CG34157

Klonalität: Monoklonal (DYS-48)

Wirt: Bitte anfragen

Reaktivität: Human, Maus, Ratte (Rattus), Huhn

Applikation: Western Blot (WB)

Produktnummer: ABIN343580

Produktbeschreibung

Weitere Bezeichnung: Dystrophin

Immunogen: Recombinant human dystrophin fragment. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotyp: IgG2b

Klon: DYS-48

Beschreibung: Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons, the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain. overexpression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.

Spezifität: Human, mouse, rat, chicken. No cross reactivity with other proteins.

Synonyme: DMD, MGC155049, Dmd, MGC83347, DKFZp459C1629, dmd, MGC79631, DKFZp468A1620, Dp71, cb664, zfDYS, im:6911785, zgc:110165, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, mdx, pke, Dp427, DXSmh7, DXSmh9, RATDMD, DNADMD1, CG17750, CG31175, CG7240, CG7243, CG7344, DLP, DLP1, DLP186, DLP2, DLP3, DmDLP, DmDYS, Dp205, GI3046716, dmDp186, DmelCG34157, CG34157

Anwendungen

Applikationshinweise: Western blotting: At 1-2 µg/ml with the appropriate system to detect dystrophin in cells and tissues. Immunohistochemistry (Paraffin-embedded Sections): At 2-4 µg/ml to detect dystrophin in formalin fixed and paraffin embedded tissues. Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Forschungsgebiet: Stammzellen, Zytoskelett, Mikrofilamente, Extrazelluläre Matrix

Beschränkungen: Nur für Forschungszwecke einsetzbar