ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antikörper

Antigen: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1)

Synonyme: CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, MGC163296, Abcb1, Mdr1a, ABCB1, ABCB4, CMDR1, xemdr, p-gp

Klonalität: Monoklonal (PG-13)

Wirt: Bitte anfragen

Reaktivität: Human

Applikation: Western Blot (WB), Immunzytochemie (ICC), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (Gefrierschnitte) (IHC (fro))

Produktnummer: ABIN343558

Produktbeschreibung

Weitere Bezeichnung: P-Glycoprotein(MDR)

Immunogen: A mixture of human and hamster drug-resistant whole cells and crude plasma membranes. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotyp: IgG1

Klon: PG-13

Beschreibung: P-Glycoprotein, also knows as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette tra nsporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

Spezifität: Human. No cross reactivity with other proteins.

Anwendungen

Applikationshinweise: Western blotting: At 0.5-1 µg/ml with the appropriate system to detect MDR in cells and tissues. Immunohistochemistry (Paraffin-embedded Sections): At 1-2 µg/ml to detect MDR in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Immunohistochemistry(F) At 1-2 µg/ml to detect MDR in formalin or acetone fixed tissues. Immunocytochemistry Suitable Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Beschränkungen: Nur für Forschungszwecke einsetzbar