Adrenergic, alpha-2-, Receptor (ADRA2) Antikörper

Antigen: Adrenergic, alpha-2-, Receptor (ADRA2)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Kaninchen, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN343502

Produktbeschreibung

Weitere Bezeichnung: Alpha 2 Adrenergic Receptor, ADRA2

Immunogen: A synthetic peptide corresponding to a sequence mapping near the C-terminal of human ADRA2, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Alpha-2-adrenergic receptor (ADRA2), also known as platelet type adrenoceptor alpha-2A ,is a member of G protein-coupled receptor superfamily. This gene, which can identify a DraI RFLP of the ADRAR gene, mapped to 10q23-q25, is found in the distal region of mouse chromosome 19 and abundantly expressed in giant cell. ADRA2 acts a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. It has 3 highly homologous subtypes: ADRA2A, ADRA2B and ADRA2C. Studies in mouse suggested that both the ADRA2A and ADRA2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. ADRA2A receptors inhibited transmitter release at high stimulation frequencies, whereas the ADRA2C subtype modulated neurotransmission at lower levels of nerve activity.

Spezifität: Human, rabbit, mouse, rat. No cross reactivity with other proteins.

Anwendungen

Applikationshinweise: Western blotting: At 1ug/ml with the appropriate system to detect ADRA2 in cells and tissues. Other applications have not been tested. Optimal dilutions should be determined by end user.

Reinheit: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4 , 0.05mg Thimerosal, 0.05mg NaN3

Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemical analysis of paraffin-embedded Rat Tissue sections (brain). Staining ADRA2 in cytoplasmDAB chromogenic reaction