CMKLR1 / ChemR23 (N-Term) Antikörper

Antigen: CMKLR1 / ChemR23 (N-Term)

Klonalität: Monoklonal (BZ332)

Wirt: Ratte

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN337260

Produktbeschreibung

Swiss-Prot: Q99788

Immunogen: Peptide corresponding to an epitope within the N-terminal region of human CMKLR1.

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: BZ332

Beschreibung: Gene: CMKLR1 / ChemR23, Standard Gene Symbol: CMKLR1, Family: GPCR, Subfamily: Chemoattractant, Synonyms: CMKLR1, CHEMERINR, Chemokine-like receptor 1, ChemR23, DEZ, G protein-coupled receptor dez, Gpcr27, MGC126105, MGC126106

Spezifität: Recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC's are recruited to sites of bleeding and tissue damage

Anwendungen

Applikationshinweise: Flo (1:25 - 1:100), IHC-P (10 µg/ml)

Reinigung: Protein G Column

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Lagerung: +4°C or -20°C, Avoid repeated freezing and thawing.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Human Placenta (formalin-fixed, paraffin-embedded) stained with CMKLR1 antibody ABIN337260 at 10 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.