tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) Antikörper

Antigen: tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE)

Synonyme: MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465, AU019196, 14-3-3e, 14-3-3, 14-3-3-e, CT24092, D14-3-3e, D14-3-3epsilon, EK3-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, l(3)j2B10, DmelCG31196, CG31196, LOC443300, YWHAE, mds, mdcr, kcip-1, MGC89915, 14-3-3epsilon, LOC581376, Ywhae, ACYPI002517, ywhae, zgc:55377, zgc:77062, wu:fb48f06, wu:fi22e10, MGC53170

Klonalität: Monoklonal (5A5)

Wirt: Maus

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN336074

Produktbeschreibung

Produktmerkmale: Synonyms: 14-3-3E, YWHAE

Weitere Bezeichnung: 14-3-3 protein epsilon

Swiss-Prot: P62258

Immunogen: Recombinant Human 14-3-3 epsilon (1-255 aa) purified from E. coli.

Kreuzreaktivität: Human, Maus

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: 5A5

Beschreibung: The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpointcontrol, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved andubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ and η that havebeen identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins,was thought to be brain and neuron-specific. It has been shown to interact with CDC25phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activitiesrelated to signal transduction, such as cell division and regulation of insulin sensitivity. Ithas also been implicated in the pathogenesis of small cell lung cancer.

Spezifität: The antibody recognizes Human and Mouse 14-3-3 epsilon. Other species not tested.

Synonyme: MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465, AU019196, 14-3-3e, 14-3-3, 14-3-3-e, CT24092, D14-3-3e, D14-3-3epsilon, EK3-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, l(3)j2B10, DmelCG31196, CG31196, LOC443300, YWHAE, mds, mdcr, kcip-1, MGC89915, 14-3-3epsilon, LOC581376, Ywhae, ACYPI002517, ywhae, zgc:55377, zgc:77062, wu:fb48f06, wu:fi22e10, MGC53170

Anwendungen

Applikationshinweise: ELISA. Western blot: 1/1,000-1/2,000. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1.0 mg/ml

Reinigung: Purified

Buffer: PBS, pH 7.4, containing 0.09% Sodium Azide as preservative

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar