Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1) Antikörper (PE)

Antigen: Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1)

Synonyme: A1, Ly49a, Ly49v, Klra22, Ly49o<129>

Klonalität: Monoklonal (A1)

Wirt: Maus

Reaktivität: Maus

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN335510

Produktbeschreibung

Weitere Bezeichnung: LY-49A

Isotyp: IgG2a

Klon: A1

Beschreibung: This A1 monoclonal antibody reacts with Ly49A, a 44­kDa member of the Ly49 family of type II transmembrane receptors expressed on natural killer (NK) cells. This receptor is present as a disulfide­linked homodimer with C­type lectin extracellular domains. An inhibitory receptor, Ly49A binds MHC class I molecules, such as H­2Dd, H­2Dk, and H­2DP, to inhibit NK­mediated cytotoxicity by triggering phosphorylation of its ITIM domain and recruitment of SHP­1 and SHP­2. Ly49A is expressed on DX5+CD3­ NK cells and DX5+CD3+ NK T cells, as well as on a population of memory CD8+ T cells in C57BL/6, C57BL/10, and B10 congenic mice.

Anwendungen

Applikationshinweise: This A1 (Ly49A) antibody has been tested by flow cytometric analysis on C57BL/6 splenocytes. This can be used at less than or equal to 0.5 ug per million cells in a 100 ul total staining volume. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Buffer: aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary

Lagerung: Store at 4°C.DO NOT FREEZE.LIGHT­SENSITIVE MATERIAL.

Forschungsgebiet: Zell-/Gewebemarker, Immunologie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Staining of CD3­ (cat. 11­0031) C57Bl/6 splenocytes with APC anti­ mouse pan­NK (DX5) (cat. 17­5971) and 0.125 ug of PE Mouse IgG2a, K Iso Cntrl (cat. 12­4724) (left) or 0.25 ug of PE anti­ mouse Ly­49A (A1­Ly49A) (right).