8-OHDG Antikörper

Produktnummer ABIN335419

Produktdetails anti-8-OHDG Antikörper

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Reaktivität: Bitte anfragen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser 8-OHDG Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Spezifität: 8-OHDG in all species. No observable crossreactivity for the following analogues: guanosine (G), 7methylG, 6SHG, 8bromoG, dA, dC, dT, dI, dU, dG, O6methyldG, 8OHdA, guanine (Gua), O6methylGua, 8OHGua, uric acid, Urea, creatine, creatinine Slight but minimal (<1 %) crossreactivity for the following analogues: 8sulfhydrylG and 8OHG 1

Aufreinigung: Prepared as ascites then ammonium sulphate purified

Immunogen: 8-OHdG-conjugated Keyhole Limpet Hemocyanin

Klon: N45-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Tested for IHC and ELISA. User should determine optimum titer for each application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized as 100 ug/mL IgG in10 mM Phosphate buffered saline, pH7.4 containing 1.0 % BSA.

Lagerung: -20 °C

Referenzen für anti-8-OHDG Antikörper (ABIN335419)

Lim, Shin, Luo, Quan, Cui, Ko, Chung, Yang: "Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury." in: Aging, Vol. 11, Issue 15, pp. 5548-5569, (2020) (PubMed).

Luo, Yu, Quan, Shin, Lee, Kim, Ko, Chung, Lim, Yang: "Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury." in: Scientific reports, Vol. 9, Issue 1, pp. 7995, (2019) (PubMed).

Wang, Li, Qiao, Xue, Zheng, Chen, Zeng, Liu, Boldogh, Ba: "OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos." in: Cell death & disease, Vol. 9, Issue 6, pp. 628, (2019) (PubMed).

Zhang, Lu, Yu, Wang, Yan, Zhang, Li, Wang, Wen: "Echinacoside Alleviates UVB Irradiation-Mediated Skin Damage via Inhibition of Oxidative Stress, DNA Damage, and Apoptosis." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 6851464, (2018) (PubMed).

Lim, Jin, Luo, Jin, Shin, Hong, Yang: "Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress." in: Cell death & disease, Vol. 8, Issue 8, pp. e2972, (2018) (PubMed).

Zaidi, Jelveh, Mahmood, Hill: "Effects of lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiation." in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 105, Issue 3, pp. 341-9, (2013) (PubMed).

Baila, Ohno, Nagamoto, Kotosai, Yabuuchi, Funaguchi, Ito, Endo, Mori, Takemura, Fujiwara, Fujiwara, Minatoguchi: "Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits." in: Biological & pharmaceutical bulletin, Vol. 35, Issue 4, pp. 494-502, (2012) (PubMed).

Sintara, Thong-Ngam, Patumraj, Klaikeaw: "Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats." in: Journal of biomedicine & biotechnology, Vol. 2012, pp. 915380, (2012) (PubMed).

Toyokuni, Hirao, Wada, Nagai, Date, Yoshii, Akatsuka, Yamashita, Kawada: "Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis." in: Journal of clinical biochemistry and nutrition, Vol. 49, Issue 2, pp. 121-4, (2011) (PubMed).

Sun, Sugiyama, Masuda, Ochi, Takeuchi: "Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 9, pp. 1185-90, (2011) (PubMed).

Calveley, Jelveh, Langan, Mahmood, Yeung, Van Dyk, Hill: "Genistein can mitigate the effect of radiation on rat lung tissue." in: Radiation research, Vol. 173, Issue 5, pp. 602-11, (2010) (PubMed).

Rabbani, Mi, Zhang, Delong, Jackson, Fleckenstein, Salahuddin, Zhang, Clary, Anscher, Vujaskovic: "Hypoxia inducible factor 1alpha signaling in fractionated radiation-induced lung injury: role of oxidative stress and tissue hypoxia." in: Radiation research, Vol. 173, Issue 2, pp. 165-74, (2010) (PubMed).

Mori, Nakamachi, Ohtaki, Yofu, Sato, Endo, Iso, Suzuki, Takeyama, Shintani, Hashimoto, Baba, Shioda: "Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 74, Issue 6, pp. 1183-90, (2010) (PubMed).

Yamada, Ryo, Tai, Tamaki, Inoue, Mishima, Tsubota, Saito: "Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion." in: Journal of clinical biochemistry and nutrition, Vol. 47, Issue 2, pp. 130-7, (2010) (PubMed).

Herbas, Ueta, Ichikawa, Chiba, Ishibashi, Shichiri, Fukumoto, Yokoyama, Takeya, Xuan, Arai, Suzuki: "Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice." in: Malaria journal, Vol. 9, pp. 101, (2010) (PubMed).

Raz, Zhang, Zhou, Han, Gulati, Yang, Yang, Wang, Brann: "Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat." in: PLoS ONE, Vol. 5, Issue 9, pp. e12606, (2010) (PubMed).

Du, Wooten, Gearing, Wooten: "Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease." in: Free radical biology & medicine, Vol. 46, Issue 4, pp. 492-501, (2009) (PubMed).

Fujita, Miyachi, Tanaka, Takeo, Nakagawa, Kobayashi, Iwasa, Watanabe, Takei: "Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 2, pp. 424-32, (2009) (PubMed).

Ueno, Torimura, Nakamura, Sivakumar, Nakayama, Otabe, Yuan, Yamada, Hashimoto, Inoue, Koga, Sata: "Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue." in: International journal of molecular medicine, Vol. 24, Issue 1, pp. 17-22, (2009) (PubMed).

Celino, Yamaguchi, Miura, Miura: "Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica)." in: Reproduction (Cambridge, England), Vol. 138, Issue 2, pp. 279-87, (2009) (PubMed).

Details zu 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Andere Bezeichnung: 8 Hydroxyguanosine (8-OHDG) (8-OHDG Produkte)

Substanzklasse: Chemical

Hintergrund: 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for 8-OHdG, and is suitable for immunohistochemistry. Cross reactivity have been checked for 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).