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Selectin E/CD62e Antikörper

SELE Reaktivität: Human, Maus WB, ELISA, FACS, IP, Func Wirt: Ratte Monoclonal UZ4 unconjugated
Produktnummer ABIN335383
  • Target Alle Selectin E/CD62e (SELE) Antikörper anzeigen
    Selectin E/CD62e (SELE) (Selectin E (SELE))
    Reaktivität
    • 88
    • 25
    • 22
    • 12
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 58
    • 49
    • 12
    • 2
    • 1
    • 1
    Ratte
    Klonalität
    • 64
    • 59
    Monoklonal
    Konjugat
    • 68
    • 16
    • 14
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Selectin E/CD62e Antikörper ist unkonjugiert
    Applikation
    • 62
    • 39
    • 35
    • 34
    • 24
    • 22
    • 15
    • 13
    • 10
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Spezifität
    UZ4 recognizes the minimal amino acid consensus sequence CXKKKL present in the lectin domain of both murine and human E-selectin. UZ4 is a functional antibody in that it inhibits leukocyte adhesion to both murine and human activated endothelial cells. For in vivo application in mice 20µg of purified Ig per injection is recommended.
    Aufreinigung
    Purified
    Immunogen
    UZ4 is a rat monoclonal IgM antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a Lewis rat immunized with LPS-activated mlEND1 cells expressing E-selectin at their cell surface.
    Klon
    UZ4
    Isotyp
    IgM
    Top Product
    Discover our top product SELE Primärantikörper
  • Applikationshinweise
    UZ4 is also suitable for immunoblotting, ELISA, immunoprecipitation and flow cytometry (dilution 1:500). It is not optimal for immunohistochemistry; to analyze mouse E-selectin protein in frozen sections, please refer to the anti Eselectin monoclonal antibodies UZ5, UZ6, and UZ7.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1mg/ml
    Buffer
    Purified rat monoclonal antibody at a concentration of 1mg/ml in PBS without azide!
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Kneilling, Mailhammer, Hültner, Schönberger, Fuchs, Schaller, Bukala, Massberg, Sander, Braumüller, Eichner, Maier, Hallmann, Pichler, Haubner, Gawaz, Pfeffer, Biedermann, Röcken: "Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation." in: Blood, Vol. 114, Issue 8, pp. 1696-706, (2009) (PubMed).

    Hammel, Weitz-Schmidt, Krause, Moll, Vestweber, Zerwes, Hallmann: "Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion." in: Experimental cell research, Vol. 269, Issue 2, pp. 266-74, (2001) (PubMed).

    Wolf, Hallmann, Sass, Sixt, Küsters, Fregien, Trautwein, Tiegs: "TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 2, pp. 1300-7, (2001) (PubMed).

    Sunderkötter, Seeliger, Schönlau, Roth, Hallmann, Luger, Sorg, Kolde: "Different pathways leading to cutaneous leukocytoclastic vasculitis in mice." in: Experimental dermatology, Vol. 10, Issue 6, pp. 391-404, (2001) (PubMed).

    Alferink, Tafuri, Vestweber, Hallmann, Hämmerling, Arnold: "Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1338-41, (1998) (PubMed).

    Tietz, Allemand, Borges, von Laer, Hallmann, Vestweber, Hamann: "CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 2, pp. 963-70, (1998) (PubMed).

    Austrup, Vestweber, Borges, Löhning, Bräuer, Herz, Renz, Hallmann, Scheffold, Radbruch, Hamann: "P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues." in: Nature, Vol. 385, Issue 6611, pp. 81-3, (1997) (PubMed).

    Borges, Tietz, Steegmaier, Moll, Hallmann, Hamann, Vestweber: "P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin." in: The Journal of experimental medicine, Vol. 185, Issue 3, pp. 573-8, (1997) (PubMed).

    Hallmann, Zimmermann, Sorokin, Needham, Von der Mark: "Adhesion of leukocytes to the inflammed endothelium." in: Scandinavian journal of rheumatology. Supplement, Vol. 101, pp. 107-9, (1995) (PubMed).

  • Target
    Selectin E/CD62e (SELE) (Selectin E (SELE))
    Andere Bezeichnung
    E-selectin (SELE Produkte)
    Synonyme
    SELE antikoerper, CD62E antikoerper, ELAM antikoerper, ELAM1 antikoerper, ESEL antikoerper, LECAM2 antikoerper, E-selectin antikoerper, Elam antikoerper, selectin E antikoerper, selectin, endothelial cell antikoerper, SELE antikoerper, Sele antikoerper
    Hintergrund
    BACKGROUND Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFα and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFκB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
    Pathways
    Thromboxane A2 Receptor Signaling
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