G Protein-Coupled Receptor 68 (GPR68) Antikörper

Antigen: G Protein-Coupled Receptor 68 (GPR68)

Synonyme: OGR1, MGC111379, MGC156983, Ogr1, BB131428, GPR68

Klonalität: Monoklonal (15B8)

Wirt: Maus

Reaktivität: Human

Applikation: ELISA, Western Blot (WB)

Produktnummer: ABIN335189

Produktbeschreibung

Weitere Bezeichnung: GPR68

Gen-ID: 8111

Immunogen: Partial peptide of Human GPR68

Format: Affinity-purified

Isotyp: IgG2b, kappa chain  (Passende Sekundärantikörper)

Klon: 15B8

Beschreibung: GPR68 (also known as OGR1: ovarian cancer G protein-coupled receptor 1) is a member of G protein-coupled receptor and was initially cloned from the ovarian cancer cell line. ORG1 is expressed in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, but not detectable in ovary. GPR68 is one of the proton-sensing GPCR that is a receptor for sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC). In cells expressing GPR68, extracellular acidic pH induced the stimulation of inositol phosphate production and cAMP accumulation. It has also been shown that GPR68 is expressed early during osteoclastogenesis and may play a role in osteoclast differentiation.

Anwendungen

Applikationshinweise: WB: 20ug/ml, ELISA: 1ug/ml

Konzentration: 0.25 mg/ml

Reinigung: ProteinG affinity purified

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Lagerung: Store below -20C

Forschungsgebiet: Immunologie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Sample: lysates from human cancer cell lines. 1. Human adenocarcinoma cell line derived from lung cancer. 2. stomach, adenosquamous carcinoma 3. colon, adenocarcinoma 4. Human hepatoma cell line. 5. Human pancreatic ductal adenocarcinoma line 6. Human cell line derived from esophageal cancer. Squamous cell carcinoma. 7. Human metastatic mammary carcinoma cell line.

Publikationen

Publikationen: Xu, Casey: "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14." in: Genomics, Vol. 35, Issue 2, pp. 397-402, 1996 (PubMed).

Ludwig, Vanek, Guerini et al.: "Proton-sensing G-protein-coupled receptors." in: Nature, Vol. 425, Issue 6953, pp. 93-8, 2003 (PubMed).

Mogi, Tomura, Tobo et al.: "Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation." in: Journal of pharmacological sciences, Vol. 99, Issue 2, pp. 160-7, 2005 (PubMed).

Yang, Mailhot, Birnbaum et al.: "Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis." in: The Journal of biological chemistry, Vol. 281, Issue 33, pp. 23598-605, 2006 (PubMed).