Integrin alpha M (ITGAM) Antikörper (FITC)

Antigen: Integrin alpha M (ITGAM)

Synonyme: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, MGC117044, CR3, MAC1, Cd11b, Ly-40, Mac-1, Mac-1a, CD11b/CD18, F730045J24Rik, ITGAM, Itgam

Klonalität: Monoklonal (MCD11b)

Wirt: Ratte

Reaktivität: Maus

Konjugat: FITC

Applikation: Blockierende Antikörper (Inhibition), Immunhistochemie (IHC), Funktionale Studien (Func)

Produktnummer: ABIN334848

Produktbeschreibung

Weitere Bezeichnung: CD11b

Immunogen: Purified mouse LN CD4+ T cells

Isotyp: IgG2b

Klon: MCD11b

Beschreibung: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain. Synonyms: Integrin, alpha M, CR3A, MO1A, CD11B, MAC-1, MAC1A, MGC117044, ITGAM.

Anwendungen

Applikationshinweise: Staining and blocking antibody. For staining, use 10 ul/106 cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator Available Conjugates: This antibody is only available conjugated to FITC.

Konzentration: 1mg/ml in PBS (after reconstitution)

Reinigung: Ion exchange column

Lagerung: Storage: Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf Life: Two years lyophilized, one month in solution at 4°C.

Forschungsgebiet: Stammzellen, Hämopoetische Vorläufer, Hämatopoetische Stammzellen, Glia Marker, CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar