CD14 Molecule (CD14) Antikörper

Antigen: CD14 Molecule (CD14)

Synonyme: CD14

Klonalität: Monoklonal (HCD4)

Wirt: Maus

Reaktivität: Human

Applikation: Blockierende Antikörper (Inhibition), Immunhistochemie (IHC)

Produktnummer: ABIN334823

Produktbeschreibung

Weitere Bezeichnung: CD14

Immunogen: Purified human B Cells

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: HCD4

Beschreibung: CD14 (also known lipopolysaccharide (LPS) receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells. Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein.

Anwendungen

Applikationshinweise: Blocking and staining antibody. For staining, use 10ul/106 cells. Titer for blocking LPS binding should be determined by the investigator. Available Conjugates: This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10ul/106 cells.

Reinigung: Ion exchange column

Lagerung: Storage: Lyophilized: store at 4(C. After reconstitution, if not intended for use within a month, aliquot and store at -20(C. Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf Life: Two years lyophilized, one month in solution at 4(C.

Forschungsgebiet: Stammzellen, Angeborene Immunität, Hämopoetische Vorläufer, Hämatopoetische Stammzellen, CD Antigene, Oberflächenrezeptoren der Immunzellen , Apoptose/Nekrose, Immunologie, Inflammation

Beschränkungen: Nur für Forschungszwecke einsetzbar