Interleukin 15 (IL15) Antikörper

Antigen: Interleukin 15 (IL15)

Synonyme: IL-15, MGC9721, AI503618, IL15

Klonalität: Monoklonal (YNR-HIL15)

Wirt: Maus

Reaktivität: Human

Applikation: ELISA, Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN334751

Produktbeschreibung

Weitere Bezeichnung: Interleukin-15

Immunogen: recombinant Human IL-15

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: YNR-HIL15

Beschreibung: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. Synonyms: IL-15, MGC9721.

Anwendungen

Applikationshinweise: By direct ELISA, 1:20,000 dilution will yield >1.0 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).

Konzentration: 1mg/ml in PBS (after reconstitution)

Reinigung: Ion exchange

Lagerung: Shipping Condition: Antibody is shipped lyophilized at ambient temperature. Storage: In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf Life: Two years lyophilized, one month in solution at 4°C.

Beschränkungen: Nur für Forschungszwecke einsetzbar