Pancreas Duodenum Homeobox-1 Antikörper

Antigen: Pancreas Duodenum Homeobox-1

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN334704

Produktbeschreibung

Immunogen: Recombinant PDX1 E.Coli derived Specificity: Human and Mouse PDX-1 Molecular Weight: 35-4 kDa Stability: Stable for 2 yeas at -2

Beschreibung: PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. during development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. at adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Synonyms: IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1.

Anwendungen

Applikationshinweise: Western Blot: 1:1,000 Immunohistochemistry: 1:500 Optimal working dilutions must be determined by end user. Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1.

Konzentration: 1mg/ml in PBS (after reconstitution)

Beschränkungen: Nur für Forschungszwecke einsetzbar