Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antikörper (Biotin)

Details zu Produkt Nr. ABIN320244, Anbieter: Anmelden zum Anzeigen
Antigen
  • MADCAM1
  • AV211525
  • MACAM1
  • mucosal vascular addressin cell adhesion molecule 1
  • MADCAM1
  • Madcam1
  • MADCAM-1
Reaktivität
Human
129
100
33
2
Wirt
Maus
105
61
45
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Biotin
26
14
8
6
6
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
117
110
45
43
37
29
26
23
10
10
7
3
2
2
2
2
2
2
1
1
1
1
1
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Immunogen Recombinant soluble MAdCAM-1-fc fusion protein. Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3X63Ag8.653 myeloma cell line.
Klon 17F5
Isotyp IgG1
Spezifität This antibody recognises mucosal addressin cell adhesion molecule 1 (MAdCAM-1). Clone 17F5 recognises the mucin domain of MAdCAM-1. This antibody does not block the function of MAdCAM-1.
Reinigung Affinity chromatography on Protein G
Andere Bezeichnung MAdCAM1 (MADCAM1 Antibody Abstract)
Hintergrund MAdCAM-1 is a 60kD transmembrane protein that belongs to the immunoglobulin superfamily. MAdCAM-1 is strongly expressed on mucosal lymphoid tissue and high endothelial venules of Peyers patches. Human MAdCAM-1 interacts with the beta 7 integrin LPAM-1 (alpha4beta7), CD62L, and VLA-4 (alpha4beta1) and is involved in lymphocyte trafficking.Synonyms: MAdCAM-1, Mucosal addressin cell adhesion molecule 1, hMAdCAM-1
Gen-ID 8174
NCBI Accession NP_570116
UniProt Q13477
Applikationshinweise Flow Cytometry: neat - 1/10, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. ELISA: 1 μg/mL - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Allgemeine Veröffentlichungen Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: "Bioassay detects soluble MAdCAM-1 in body fluids." in: Immunology and cell biology, Vol. 82, Issue 4, pp. 400-9, 2004 (PubMed).

Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." in: Immunology and cell biology, Vol. 74, Issue 6, pp. 490-6, 1997 (PubMed).