Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antikörper (PE)

Details zu Produkt Nr. ABIN320243, Anbieter: Anmelden zum Anzeigen
Antigen
  • MADCAM1
  • AV211525
  • MACAM1
  • mucosal vascular addressin cell adhesion molecule 1
  • MADCAM1
  • Madcam1
  • MADCAM-1
Reaktivität
Human
129
100
33
2
Wirt
Maus
105
61
45
1
Klonalität (Klon)
Monoklonal ()
Konjugat
PE
27
14
8
6
5
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Flow Cytometry (FACS)
117
110
45
43
37
29
26
23
11
10
7
3
2
2
2
2
2
2
1
1
1
1
1
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Immunogen Recombinant soluble MAdCAM-1-fc fusion protein. Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3X63Ag8.653 myeloma cell line.
Klon 314G8
Isotyp IgG1
Spezifität This antibody recognises mucosal addressin cell adhesion molecule 1 (MAdCAM-1). Clone 314G8 does not recognise MAdCAM-1 in the gut lamina propria. Clone 314G8 reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognised by clone 314G8. Clone 314G8 is reported to block the interaction of MAdCAM-1 with alpha 4 beta 7 (in press). We recommend the use of SM2237F for this purpose.
Reinigung Affinity chromatography on Protein G
Andere Bezeichnung MAdCAM1 (MADCAM1 Antibody Abstract)
Hintergrund MAdCAM-1 is a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyers patches and mesenteric lymph nodes. MAdCAM-1 expression has also been reported in the gut lamina propria.Synonyms: MAdCAM-1, Mucosal addressin cell adhesion molecule 1, hMAdCAM-1
Gen-ID 8174
NCBI Accession NP_570116
UniProt Q13477
Applikationshinweise Flow Cytometry: neat - 1/10, use 10 μL of the suggested working dilution to label 106 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Restore with 1.0 mL distilled water
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Can be shipped at 4 °C. Store at -20 °C only.
Allgemeine Veröffentlichungen Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." in: Immunology and cell biology, Vol. 74, Issue 6, pp. 490-6, 1997 (PubMed).