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SYK Antikörper (AA 321-325)

SYK Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN319416
  • Target Alle SYK Antikörper anzeigen
    SYK (Spleen tyrosine Kinase (SYK))
    Bindungsspezifität
    • 29
    • 22
    • 20
    • 16
    • 10
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 321-325
    Reaktivität
    • 176
    • 88
    • 53
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human
    Wirt
    • 158
    • 23
    • 3
    Kaninchen
    Klonalität
    • 161
    • 22
    Polyklonal
    Konjugat
    • 107
    • 12
    • 10
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser SYK Antikörper ist unkonjugiert
    Applikation
    • 149
    • 84
    • 46
    • 26
    • 23
    • 19
    • 14
    • 14
    • 13
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of total Syk protein.
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific immunogen.
    Immunogen
    Peptide sequenece around amino acids 321~325 (N-P-Y-E-P) derived from Human Syk.
    Top Product
    Discover our top product SYK Primärantikörper
  • Applikationshinweise
    Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200. Immunohistochemistry on Paraffin Sections: 1/50approx. 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    SYK (Spleen tyrosine Kinase (SYK))
    Andere Bezeichnung
    SYK (SYK Produkte)
    Synonyme
    p72-Syk antikoerper, Sykb antikoerper, p72syk antikoerper, spleen associated tyrosine kinase antikoerper, spleen tyrosine kinase antikoerper, syk antikoerper, SYK antikoerper, Syk antikoerper
    Hintergrund
    Syk (72 kDa) is a non receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.Synonyms: Spleen tyrosine kinase, Tyrosine-protein kinase SYK
    Gen-ID
    6850
    NCBI Accession
    NP_001128524
    UniProt
    P43405
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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