CASP14
Reaktivität: Human, Maus, Ratte
ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Western Blot: 1 - 2g/mL, detects a band of approximately 27 kDa in Jurkat cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Caspase-14 is a 27kD cysteine protease which is activated by zymogen processing during cellular differentiation. It is highly expressed by keratinocytes and trophoblast cells of the placenta, with lower expression in the choroid plexus, the pigmented layer of the retina, and hair follicles. Expression of the caspase-14 gene has recently been identified in epithelial tumours, including cervical and bladder carcinoma. The biological function of caspase-14 in tumour and normal tissue remains to be classified.Synonyms: CASP-14, CASP14