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BAG1 Antikörper (N-Term)

BAG1 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN318740
  • Target Alle BAG1 Antikörper anzeigen
    BAG1 (BCL2-Associated Athanogene (BAG1))
    Bindungsspezifität
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 34
    • 19
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 31
    • 8
    Kaninchen
    Klonalität
    • 30
    • 9
    Polyklonal
    Konjugat
    • 32
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BAG1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 14
    • 12
    • 11
    • 10
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody detects an epitope within the N-terminal (NT) region of Bcl-2 associated athanogene-1 (BAG1).
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse.
    Aufreinigung
    Affinity chromatography
    Immunogen
    14 amino acid peptide near the amino terminus of human BAG1.
    Isotyp
    IgG
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  • Applikationshinweise
    Western Blot: 1 - 2g/mL, detects a band of approximately 35 kDa in PC3 cell lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline containing 0.02 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    BAG1 (BCL2-Associated Athanogene (BAG1))
    Andere Bezeichnung
    BAG1 (BAG1 Produkte)
    Synonyme
    BAG-1 antikoerper, HAP antikoerper, RAP46 antikoerper, Rap46 antikoerper, Bag-1 antikoerper, ATBAG1 antikoerper, BCL-2-associated athanogene 1 antikoerper, MSG15.15 antikoerper, MSG15_15 antikoerper, im:7148830 antikoerper, si:dkey-216e9.4 antikoerper, BCL2 associated athanogene 1 antikoerper, putative bcl2-associated athanogene antikoerper, BCL2-associated athanogene 1 antikoerper, Bcl2 associated athanogene 1 antikoerper, BAG family molecular chaperone regulator 1 antikoerper, BCL-2-associated athanogene 1 antikoerper, BAG1 antikoerper, Smp_005900 antikoerper, Bag1 antikoerper, bag-1 antikoerper, LOC781741 antikoerper, bag1 antikoerper
    Hintergrund
    BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms, a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.Synonyms: BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46
    Gen-ID
    573
    NCBI Accession
    NP_001165886
    UniProt
    Q99933
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