G Protein-Coupled Receptor 132 Antikörper

Produktnummer ABIN317643

Produktdetails anti-G Protein-Coupled Receptor 132 Antikörper

Target: G Protein-Coupled Receptor 132 (GPR132)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser G Protein-Coupled Receptor 132 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of G2A protein.(region surrounding Lys327)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu G Protein-Coupled Receptor 132

Target: G Protein-Coupled Receptor 132 (GPR132)

Andere Bezeichnung: GPR132 / G2A (GPR132 Produkte)

Synonyme: G2A antikoerper, G2a antikoerper, G protein-coupled receptor 132 antikoerper, GPR132 antikoerper, gpr132 antikoerper, Gpr132 antikoerper

Hintergrund: G2A (for G2 accumulation) is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells. G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation. Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition. G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties. The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation.Synonyms: G-protein coupled receptor 132, G2 accumulation protein

Molekulargewicht: approx. 42 kDa

Gen-ID: 29933

NCBI Accession: NP_037477

UniProt: Q9UNW8