VTCN1 Antikörper (V-Set Domain Containing T Cell Activation Inhibitor 1) (AA 7-4) (FITC)

Details for Product anti-VTCN1 Antibody No. ABIN317041, Anbieter: Anmelden zum Anzeigen
Antigen
  • B7h4
  • B7s1
  • B7x
  • BC032925
  • B7-H4
  • B7H4
  • B7S1
  • B7X
  • B7h.5
  • PRO1291
  • VCTN1
  • RGD1311204
  • V set domain containing T cell activation inhibitor 1 L homeolog
  • V-set domain containing T cell activation inhibitor 1
  • V-set domain containing T-cell activation inhibitor 1
  • V set domain containing T cell activation inhibitor 1
  • vtcn1.L
  • VTCN1
  • vtcn1
  • Vtcn1
Epitop
AA 7-4
22
19
16
10
10
10
9
8
5
3
2
2
1
1
1
1
1
Reaktivität
Human
170
70
29
6
5
2
2
1
1
1
1
Wirt
Maus
80
61
36
33
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser VTCN1 Antikörper ist konjugiert mit FITC
21
17
16
9
7
6
4
4
4
4
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
105
95
79
28
19
13
6
6
4
3
3
3
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Human B7-H4
Klon MIH43
Isotyp IgG1
Spezifität This antibody recognises B7-H4, also known as B7x.
Produktmerkmale Synonyms: B7-H4, B7x, B7h.5, B7S1, UNQ659/PRO1291, V-set domain-containing T-cell activationinhibitor 1
Reinigung Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Andere Bezeichnung VTCN1 / B7H4 (VTCN1 Antibody Abstract)
Hintergrund B7-H4 is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected, suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).Synonyms: B7-H4, B7S1, B7h.5, B7x, UNQ659/PRO1291, V-set domain-containing T-cell activation inhibitor 1
Gen-ID 79679
UniProt Q7Z7D3
Applikationshinweise Flow Cytometry: Use 10 μL of neat-1/5 diluted antibody to label 1x10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Haltbarkeit 12 months
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 7-4) antibody (FITC) (ABIN317041) anti-V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 7-4) antibody (FITC)
Allgemeine Veröffentlichungen Krambeck, Thompson, Dong, Lohse, Park, Kuntz, Leibovich, Blute, Cheville, Kwon: "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 27, pp. 10391-6, 2006 (PubMed).

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