alpha-2-HS-Glycoprotein (AHSG) Antikörper

Antigen: alpha-2-HS-Glycoprotein (AHSG)

Synonyme: AHS, A2HS, HSGA, FETUA, fetuin-A, pp63, Aa2-066, AHSG, ahs, a2hs, hsga, fetua, MGC103687, MGC192819, wu:fb63g02, zgc:103687, MGC116429, Ahsg

Klonalität: Polyklonal

Wirt: Ziege

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN315280

Produktbeschreibung

Weitere Bezeichnung: Alpha-2-HS-glycoprotein

Gen-ID: 197

Swiss-Prot: P02765

Immunogen: Recombinant protein.

Beschreibung: Human fetuin (2-Heremans-Schmid-glycoprotein or a2-HS glycoprotein) is a majorplasma glycoprotein predominantly synthesized in the liver. Human fetuin is named afterits bovine homolog. Fetuins are found in most mammals. Human fetuin is a negativeacute-phase protein, normal circulating levels in adults (300600 g/ml) fall significantly(3050%) during injury and infection. The biological role of fetuin is unknown, although ithas been implicated as an immunomodulator that can participate in stimulation ofbacterial phagocytosis by neutrophils and promotion of endocytosis by mousemacrophages. Hepatocytes are the principal cell source of circulating fetuin, but it also isexpressed by monocyte/macrophages. Fetuins occur in large amounts in blood andcerebrospinal fluid and accumulate to high concentrations in calcified bone. The fetuinpromoter region has several potential interleukin 6-responsive elements, and itssynthesis is down-regulated during injury and inflammation. Fetuin is an acidicglycoprotein with three N-linked and three O-linked oligosaccharide chains, whoseterminal sugar residues are rich in sialic acid (N-acetylneuraminic acid), contributing toits net negative charge. A role for fetuin as a carrier of bioactive molecules has beenproposed based on observations that it binds and carries Ca2+ ion. Fetuin is implicatedin bone remodeling, immune function and may play a role in tumor progression ofcertain cell types. Fetuin plays a role as an anti-inflammatory agent by suppressing therelease of TNF from stimulated macrophages. Fetuin also interacts with members of thematrix metalloprotease family of zinc dependent secreted transmembrane proteins thatdegrade basement membranes and extracellular matrix components. The biologicalactivity of fetuin is mediated through its direct interaction with other proteins. Fetuindown-regulates a number of receptor tyrosine kinase family members. A motif withinfetuin has homology to the TGF-b receptor type II. Circulating human plasma fetuin ispartly phosphorylated which implies that phosphorylated fetuin may have a physiologicalfunction in vivo. Human fetuin isolated from plasma is a two-chain molecule consistingof a A-chain of 322 amino acid residues (53 kDa) and a B-chain of 27 residues (5 kDa).The carboxy terminal 40 amino acids of the A chain constitute a bridging peptide thatmay be removed proteolytically in vivo. A single mRNA encodes both the A and Bchains. The apparent molecular weight of intact human fetuin is 58 kDa. Alternate Names: anti-AHSG antibody, A2HS antibody, AHS antibody, ALPHA-2-Z-GLOBULIN antibody,FETUA antibody, FETUIN-A antibody, HSGA antibody.

Spezifität: Recombinant human fetuin (a2-HS glycoprotein) processed to remove a 40 amino acidresidue bridging peptide resulting in the mature form of the protein. Species Reactivity: This antibody is reactive to Human.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1:10000-1:20000

Konzentration: 1 mg/ml

Buffer: PBS. Preservative: 0.01% Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: Immunologie, Inflammation, Serum/Plasma Proteine

Beschränkungen: Nur für Forschungszwecke einsetzbar