Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 7 (SLC9A7) Antikörper

Antigen: Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 7 (SLC9A7)

Synonyme: Nhe7, nhe7, slc9a6

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN314714

Produktbeschreibung

Weitere Bezeichnung: SLC9A7 / NHE7

Gen-ID: 84679

Beschreibung: Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteinsmediating exchange of N+ and H+ ions in various tissues. The NHE catalyzes theelectroneural transport of extracellular Na+ for intracellular H+. They play a major role inregulation of intracellular pH (pHi) in addition to trans-cellular absorption of Na+, cellvolume regulation and possibly in cell proliferation. These primary functions of theNa+/H+ exchanger have been related to many pathophysiological states, includehypertension, organ growth and hypertrophy, regression of cancer and renal intestinaldisorders. At least 7 NHE isoforms (NHE1-7) have been cloned so far. They are allsimilar in their primary structure and predicted to have 10-12 transmembrane domains.The C-terminal domain of NHEs are predicted to be intracellular. NHE7 (human 725 aa,chromosome Xp11.4) is ubiquitously expressed, and predominantly localizes to thetrans-golgi network. NHE7 mediates the influx of Na+ or K+ in exchange for H+. It is~70% related to NHE6 but relatively less (~25%) homologous with other NHEs.

Spezifität: NHE-7 (D566) antibody detects endogenous levels of NHE-7 protein. Species Reactivity: This antibody is reactive against Human, Mouse.

Anwendungen

Applikationshinweise: Suggested working dilutions: ELISA 1:10000-1:20000,Western Blot 1:500-1:1000

Konzentration: 1 mg/ml

Buffer: Phosphate buffered saline, pH 7.2. Preservative: 15 mM sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar