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Activating Transcription Factor 2 (ATF2) Antikörper

Antigen

Activating Transcription Factor 2 (ATF2)
Synonyme HB16, CREB2, TREB7, CRE-BP1, MGC111558, ATF2, MGC142504, CHN1, CG12850, CG3749, dATF-2, DmelCG30420, CG30420
Klonalität Polyklonal
Wirt
Alternativen

Schaf
Reaktivität
Applikation
Alternativen Western Blot (WB)
Produktnummer ABIN314355
Menge 0.2 ml  (Varianten)
Preis 410,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper Varianten zurück nach oben

Weitere Bezeichnung ATF2
Gen-ID 1386, 11909
Immunogen IVADQT*PTPTRF (T*is phospho-threonine) residues 64.
Format Serum
Beschreibung ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a memberof the ATF/CREB family of basic region leucine zipper DNA binding proteins thatregulates transcription by binding to a consensus cAMP response element (CRE) in thepromoter of various viral and cellular genes. Many of these genes are important in cellgrowth and differentiation, and in stress and immune responses. ATF2 is a nuclearprotein that binds DNA as a dimer and can form dimers with members of the ATF/CREBand Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as ahomodimer. Several isoforms of ATF2 arise by differential splicing. The stable native fulllength ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecularinteraction of its carboxy terminal DNA binding domain with the amino terminaltransactivation domain. Following dimerization ATF2 becomes a short lived protein thatundergoes ubiquitination and proteolysis, seemingly in a proteinphosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2occurs following cellular stress induced by several genotoxic agents, inflammatorycytokines, and UV irradiation. This activation requires phosphorylation of two threonineresidues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantlyexpressed in brain. Alternate Names: anti-Activating Transcription Factor 2 antibody, anti-ATF 2 antibody, anti-ATF2 proteinantibody, anti-cAMP Response Element Binding Protein 2 antibody, anti-cAMPresponse element binding protein CRE BP1 antibody, anti-CRE BP1 antibody,anti-CREB 2 antibody, anti-CREB2 antibody, anti-CREBP1 antibody, anti-Cyclic AMPdependent transcription factor ATF 2 antibody, anti-HB 16 antibody, anti-HB16 antibody,anti-MGC111558 antibody, anti-mXBP antibody, anti-TREB 7 antibody, anti-TREB7antibody.
Spezifität Recognises human ATF2 phosphorylated on threonine 69. Cross reacts with mouse[threonine 51]Phosphorylated:Thr69. Species Reactivity: Reacts with Mouse.

Anwendungen
Alternativen Sekundärantikörper Varianten zurück nach oben

Applikationshinweise Suggested working dilutions: Western Blot 1ug/ml
Buffer PBS. Preservative: 0.1 % sodium azide.
Lagerung Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Forschungsgebiet Immunologie, Angeborene Immunität, Transkriptionsfaktoren
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper Varianten zurück nach oben

Alternativen zu Antigen "Activating Transcription Factor 2 (ATF2)", Typ "Antikörper" finden
Wirte Kaninchen (164), Maus (17), Ziege (5), Schaf (4)
Reaktivitäten Human (187), Maus (110), Ratte (Rattus) (99), Hund (4), Rind (Kuh) (3), Schwein (2), Kaninchen (2), Huhn (1), Pferd (1)
Applikationen Western Blot (WB) (123), Immunhistochemie (IHC) (65), Immunhistochemie (Paraffinschnitte) (IHC (p)) (56), Immunfluoreszenz (IF) (53), Immunpräzipitation (IP) (39), Enzyme Immunoassay (EIA) (33), ELISA (24), Durchflusszytometrie (FACS) (19), Dot Blot (Dot) (9), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (6), ELISA (Detektionsantikörper) (2), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
Konjugate Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope pThr69/51 (6), Ab-112 or 94 (5), Ab-62 or 44 (5), Ab-69 or 51 (5), Ab-71 or 53 (5), Ab-73 or 55 (5), pSer112 or 94 (5), pSer62 or 44 (5), pThr69 or 51 (5), pThr71 or 53 (5), pThr71/53 (5), pThr73 or 55 (5), pSer62/44 (4), pSer112/94 (3), pThr73/55 (3), S44 (2), S94 (2), S322 (1), pSer112, pSer94 (1), pSer340, pSer322 (1), pSer44 (1), pSer472 (1), pSer62, pSer44 (1), pSer94 (1), pThr51 (1), pThr69, pThr51 (1), pThr69/51 + pThr71/53 (1), pThr71 (1), pThr79, pThr51 (1)