RARalpha (0) (pSer369) Antikörper

Antigen: RARalpha (0)

Epitope: pSer369

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunfluoreszenz (IF)

Produktnummer: ABIN314087

Produktbeschreibung

Weitere Bezeichnung: Phospho-RARalpha (Ser369)

Immunogen: Modified peptide

Format: Purified

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: Poly6328

Beschreibung: RARalpha (retinoic acid receptor alpha) is a 51 kD member of the nuclear hormone receptor family, NR1 subfamily. Thisnuclear protein contains modulating, DNA-binding, and steroid binding domains, and has been reported to havemultiple isoforms. RARalpha is a nuclear receptor for retinoic acid that controls cell function by regulating geneexpression and inducing profound effects on vertebrate development, acting as a morphogen and powerfulteratogen. RARalpha is increased by protein kinase C stimulation, and estrogen, decreased at G0/G1 to S phase of cellcycle and in lymphocytes by cellular activation. RARalpha can be modified by phosphorylation and has been shown tointeract with NCOA3 and NCOA6 co-activators leading to strong increases in the transcription of target genes. ThePoly6328 antibody recognizes human RARalpha and has been shown to be useful for immunofluorescence microscopy.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimalperformance for each application.

Reinigung: The antibody was purified by antigen-affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.

Lagerung: Upon receipt, store frozen at -20 degrees C.

Beschränkungen: Nur für Forschungszwecke einsetzbar