Presenilin (PSEN1/PSEN2) (pSer 353/Ser357) Antikörper

Antigen: Presenilin (PSEN1/PSEN2)

Synonyme: pre1, psen, zfPS1, zf-PS1, CG5868, DPS, DPsn, DmPS, DrosPS, PS, PS1, l(3)77CDb, pres, psn, DmelCG18803, CG18803

Epitope: pSer 353/Ser357

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunfluoreszenz (IF)

Produktnummer: ABIN314085

Produktbeschreibung

Weitere Bezeichnung: Phospho-presenilin (Ser 353/Ser357)

Immunogen: Modified peptide

Format: Purified

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: Poly6366

Beschreibung: Presenilin 1 belongs to the peptidase A22A family. Predicted molecular weight approximately 53 kD. Presenilinsassemble with nicastrin, PEN-2, and APH-1 into an active g-secretase complex responsible for proteolytic cleavage ofamyloid precursor protein (APP) and transmembrane cleavage of Notch receptor proteins. Presenilin 1 is subjected toan endoproteolytic cleavage, generating a stable heterodimer composed of an N-terminal and a C-terminal fragment.Presenilin 1 may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclearmembrane and involved in stimulates cell-cell adhesion, negatively regulating Wnt signaling, and hematopoiesis.Presenilin1 residues Ser353 and Ser357 are phosphorylated by GSK-3beta. The Poly6366 antibody recognizes humanphospho-Presenilin 1 (Ser353/Ser357) and has been shown to be useful for immunoflorence staining. This antibodydoes not detect Presenilin 1 phosphorylated at other sites.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated.

Reinigung: The antibody was purified by antigen-affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.

Lagerung: Upon receipt, store frozen at -20 degrees C.

Beschränkungen: Nur für Forschungszwecke einsetzbar