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Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) Antikörper

Antigen

Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9)
Synonyme MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c, Mch6, AI115399, AW493809, Caspase-9, CASP9, LOC100101592
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human, Maus, Ratte (Rattus)
Applikation
Alternativen Western Blot (WB)
Produktnummer ABIN313819
Menge 50 ul  (Varianten)
Preis 117,14 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 5 bis 7 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper Varianten zurück nach oben

Weitere Bezeichnung Caspase 9
Immunogen peptide mapping to an internal domain within the p10 subunit of humancaspase-9
Format Purified
Klon Poly6342
Beschreibung Caspase-9 is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as aheterotetramer and has been reported to have two isoforms. Pro-Caspase-9 has been reported to be approximately47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase-9 isinvolved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase-3 andCaspase-6. Caspase-9 is inhibited by the dominant negative isoform, Bcl-XL, c-IAP1, c-IAP2, XIAP, and Livin. Thiscaspase becomes activated when recruited to Apaf-1/cytochrome c complex, and following cleavage by Apaf-1,granzyme B, Caspase-3, possibly Caspase-8 and Caspase-10 into large p37 and small p10 subunits. Caspase-9interacts with BIRC7 and has been shown to cleave PARP and vimentin. The Poly6342 antibody has been shown tobe useful for western blotting of human Human, Mouse and rat caspase-9 (p10) and caspase-9 precursor.

Anwendungen
Alternativen Sekundärantikörper Varianten zurück nach oben

Applikationshinweise Each lot of this antibody is quality control tested by Western blotting. Western blotting suggested working dilution(s): Use 10 ul per 5 ml antibodydilution buffer for each mini-gel. It is recommended that the reagent betitrated for optimal performance for each application.
Reinigung This antibody was purified by affinity chromatography.
Buffer This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 0.2% gelatin.
Lagerung The antibody solution should be stored undiluted at 4 degrees C. DO NOT FREEZE.
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper Varianten zurück nach oben

Alternativen zu Antigen "Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9)", Typ "Antikörper" finden
Wirte Kaninchen (140), Maus (20), Ziege (1)
Reaktivitäten Human (145), Ratte (Rattus) (60), Maus (57), Rind (Kuh) (21), Hund (20), Affe (4), Hamster (3), Schwein (3), Schaf (3), Kaninchen (2)
Applikationen Western Blot (WB) (118), Immunfluoreszenz (IF) (57), Durchflusszytometrie (FACS) (39), Immunhistochemie (Paraffinschnitte) (IHC (p)) (29), Immunpräzipitation (IP) (24), ELISA (22), Immunhistochemie (IHC) (16), Enzyme Immunoassay (EIA) (13), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (4), Immunzytochemie (ICC) (2), Immunoelectron Microscopy (IEM) (2)
Konjugate Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), RBITC (2)
Epitope active (7), AA 299-318 (3), pSer196 (3), C-Term (2), Center (2), Cleaved-Asp315 (2), Cleaved-Asp353 (2), N-Term (2), AA 41-56 (1), Ab-125 (1), Ab-144 (1), Ab-153 (1), Ab-196 (1), Cleaved-Asp330 (1), Intermediate Domain 2 (1), S196 (1), p10 subunit (1), p35 subunit (1), pS196 (1), pSer144 (1), pThr125 (1), pTyr153 (1)