Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Antikörper

Antigen: Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)

Synonyme: CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB), Immunpräzipitation (IP), Immunhistochemie (IHC)

Produktnummer: ABIN313817

Produktbeschreibung

Weitere Bezeichnung: Caspase 3

Immunogen: Peptide mapping to the amino terminal domain of human caspase-3prescursor

Format: Purified

Klon: Poly6341

Beschreibung: Caspase 3 is a member of the peptidase family C14. This cytoplasmic caspase functions as a heterotetramer and hastwo isoforms (one acts as a dominant negative inhibitor). The pro-form of this caspase is approximately 32 kD.Caspase 3 is involved in the caspase activation cascade responsible for apoptosis execution. Caspase 3 is inhibitedby c-IAP1, c-IAP2, XIAP, survivin, and Livin and activated by Caspase 6, -8 , and -10, granzyme B, Apaf-1 bycleavage into large p17 and small p12 subunits. Caspase 3 has been shown to cleave PARP, huntingtin, androgenreceptor, atrophin-1, DNA- PKcs, D4-GDI, hnRNPs C1/C2, U1snRNP, PKC delta, ATM, fodrin, gelsolin, ICAD, RIP,X-IAP, STAT1, topoisomerase I, vimentin, Rb, lamin B, mdm2, and beta-catenin. The poly6341 antibody has been shownto be useful for western blotting, immunoprecipitation and immunohistochemistry of human Human caspase-3precursor.

Synonyme: CC3, Lice, Yama, CPP32, Apopain, Caspase-3, A830040C14Rik, Cas3, Casp3, DECAY, Drosophila executioner caspase related to Apopain/Yama, caspase 3, DmelCG14902, CG14902, DRICE, ICE, DmelCG7788, CG7788, casp3, xcpp32, CASP3

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by Western blotting. Western blotting suggested working dilution(s): Use 25 ul per 5 ml antibodydilution buffer for each mini-gel. It is recommended that the reagent betitrated for optimal performance for each application.

Reinigung: This antibody was purified by affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing0.09% sodium azide and 0.2% gelatin.

Lagerung: The antibody solution should be stored undiluted at 4 degrees C. DO NOT FREEZE.

Beschränkungen: Nur für Forschungszwecke einsetzbar