CAK (cdk7)-Phosphorylated (Ser164/Thr170) Antikörper

Antigen: CAK (cdk7)-Phosphorylated (Ser164/Thr170)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunfluoreszenz (IF)

Produktnummer: ABIN313813

Produktbeschreibung

Immunogen: Modified peptide

Format: Purified

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: Poly6324

Beschreibung: CAK (also known as CDK-activating kinase, CDK7 and cell division protein kinase 7 is a 40 kD nuclear protein that isa member of the serine/threonine family of protein kinases, CDC2/CDKX subfamily. CAK activates cyclin-associatedkinases CDC2/CDK1, CDK2, CDK4, CDK6 by threonine phosphorylation and controls cell cycle progression, DNArepair, and RNA polymerase II transcription. CAK is activated by phosphorylation at Thr170 and is inactivated byphosphorylation at Ser164. CAK has been reported to interact with cyclin H and MAT1 to form the CAK complex, theCAK complex then interacts with core-TFIIH to form the TFIIH basal transcription factor. The Poly6324 antibody isuseful for immunofluorescence microscopy of human CAK protein.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescencemicroscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimalperformance for each application.

Reinigung: The antibody was purified by antigen-affinity chromatography.

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.

Lagerung: Upon receipt, store frozen at -20 degrees C.

Beschränkungen: Nur für Forschungszwecke einsetzbar