Retinoic Acid Early Transcript delta (Raet1d) Antikörper (PE)

Antigen: Retinoic Acid Early Transcript delta (Raet1d)

Synonyme: MGC118478, RAE-1delta

Klonalität: Monoklonal (Charlotte d1-23)

Wirt: Maus

Reaktivität: Maus

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN313128

Produktbeschreibung

Weitere Bezeichnung: RAE-1delta

Immunogen: Mouse RAE-1delta transfected RMA-S cell line

Isotyp: IgG1

Klon: Charlotte d1-23

Beschreibung: RAE-1delta is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, andepsilon. They are strong homology within the family, related by 92%-95% sequence identity. They are distantly relatedto MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue.They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found onNK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D withRAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation,cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses totumors, pathogen-infected cells, and autoimmune diseases.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is approx. 1.0 ug per 106 cells in 100 ul volume. It isrecommended that the reagent be titrated for optimal performance for each application.

Reinigung: The antibody was purified by affinity chromatography, and conjugated withPE under optimal conditions. The solution is free of unconjugated PE andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar