Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) Antikörper (PE)

Antigen: Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2)

Klonalität: Monoklonal (TX31)

Wirt: Maus

Reaktivität: Human

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN312792

Produktbeschreibung

Weitere Bezeichnung: CD112 (Nectin-2)

Isotyp: IgG1, kappa chain

Klon: TX31

Beschreibung: CD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembraneglycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes,dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells. CD112functions as a receptor for alpha-herpes viruses HSV-1 and pseudorabies virus (PRV). CD112 is an adhesion moleculeinvolved in the formation of cell junction and regulation of NK- and T-cells mediated cytotoxicity through interactionwith CD226 (DNAM-1) and other nectin family molecules.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is 20 ul per million cells or 20 ul per 100 ul ofwhole blood. It is recommended that the reagent be titrated for optimalperformance for each application. Additional reported applications include: partially block CD226-Fc bidning to CD112 transfectant and partially inhibitthe cytotoxicity mediated by NK and T cells.

Reinigung: The antibody was purified by affinity chromatography, and conjugated withPE under optimal conditions. The solution is free of unconjugated PE andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar