Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) Antikörper

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4)

Synonyme: GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, TNFRSF4, OX40, CD134, Ath1, gp34, Ath-1, Ox40l, Txgp1l, TNFSF4, Ox40, Txgp1

Klonalität: Monoklonal (OX-86)

Wirt: Ratte

Reaktivität: Maus

Applikation: Immunhistochemie (IHC), Funktionale Studien (Func)

Produktnummer: ABIN312657

Produktbeschreibung

Weitere Bezeichnung: CD134 (OX-40)

Immunogen: Recombinant mouse OX-40-CD4 chimeric protein

Isotyp: IgG1, kappa chain

Klon: OX-86

Beschreibung: CD134 is a type I integral membrane protein, also known as OX-40, ACT35, and tumor necrosis factor receptorsuperfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. TheOX-40 receptor binds to the OX-40 ligand (CD252) to provide a co-stimulatory signal that is independent of CD28.Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory boweldisease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is approx. 1.0 ug per 106 cells in 100 ul volume. It isrecommended that the reagent be titrated for optimal performance for each application. Additional reported applications (for the relevant formats) include: immunohistochemistry1 of acetone-fixed frozensections, and stimulation of T cell proliferation2. The OX-86 antibody does not block binding of CD134(OX-40) to itsligand. The LEAF

Reinheit: LEAF Purified

Reinigung: The antibody was purified by affinity chromatography.

Buffer: Phosphate-buffered solution, pH 7.2, containing no preservative. 0.2 um filter sterilized. Endotoxin level is < 0.1 EU/ug of the protein (< 0.01 ng/ug of the protein) as determined by the LAL test.

Lagerung: The antibody solution should be stored undiluted at 4 degrees C.

Beschränkungen: Nur für Forschungszwecke einsetzbar