CD51 Antikörper (Biotin)

Antigen: CD51

Klonalität: Monoklonal (NKI-M9)

Wirt: Maus

Reaktivität: Human

Konjugat: Biotin

Applikation: Durchflusszytometrie (FACS), Immunhistochemie (IHC)

Produktnummer: ABIN312204

Produktbeschreibung

Immunogen: Melonama cells

Isotyp: IgG2a, kappa

Klon: NKI-M9

Beschreibung: CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor alpha chain, or integrin alphaV. It formsheterodimer with integrin beta1 (CD29), beta3 (CD61), beta5, beta6, or beta8. CD51 contains two disulfide-linked subunits of125 kDa and 24 kDa, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts,neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51ligands. In association with its beta chains, CD51 binds vitronectin, von Willebrand factor, fibronectin,thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important rolesin leukocytes homing and rolling, mediates bone absorption and angiogenesis.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is approx. 0.5 ug per 106 cells in 100 ul. It isrecommended that the reagent be titrated for optimal performance foreach application.

Reinigung: The antibody was purified by affinity chromatography, and conjugated withbiotin under optimal conditions. The solution is free of unconjugated biotin.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4 degrees C. Do not

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-CD51 antibody (Biotin)