CD21/CD35 (CR2/CR1) Antikörper (APC)

Antigen: CD21/CD35 (CR2/CR1)

Klonalität: Monoklonal (7E9)

Wirt: Ratte

Reaktivität: Maus

Konjugat: APC

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN312094

Produktbeschreibung

Isotyp: IgG2a-kappa

Klon: 7E9

Beschreibung: CD21, also known as CR2 (complement receptor 2), C3d receptor, binds C3d and iC3b. It is also a receptor ofEpstein-Barr virus. CD35, also known as CR1, binds C3b, iC3b, C4b and iC4. CD21/CD35 is primarily expressed onB lymphocytes, mast cells, follicular dendritic cells, macrophages, and activated granulocytes. CD21/CD35 forms partof the B-cell antigen receptor complex with CD19 and CD81 and is involved in signal transduction.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is approx. 0.25 ug per 106 cells in 100 ul volume. It isrecommended that the reagent be titrated for optimal performance for eachapplication.

Reinigung: The antibody was purified by affinity chromatography, and conjugated withAPC under optimal conditions. The solution is free of unconjugated APC andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Boackle, Holers, Chen et al.: "Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein." in: Immunity, Vol. 15, Issue 5, pp. 775-85, 2001 (PubMed).