TSLPR (TSLP-R) Antikörper (APC)

Antigen: TSLPR (TSLP-R)

Klonalität: Monoklonal (1B4)

Wirt: Maus

Reaktivität: Human

Konjugat: APC

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN312083

Produktbeschreibung

Immunogen: Human TSLP-R:Fc protein

Isotyp: IgG1, kappa chain

Klon: 1B4

Beschreibung: TSLP-R, also known as thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is atype I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind TSLP. The TSLP-Rcontains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs.TSLP-R has a predicted molecular weight approximately 40 kD, and two isoforms have been reported that areproduced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells including dendritic cells andactivated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle,and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development ofthe hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory Tcells in allergic diseases.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 ul per million cells or 20 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application. For most successful immunofluorescent staining results, it may be important to maximize signal over background byusing a relatively bright fluorochrome-antibody conjugate (Cat. No. 322805/322806) or by using a high sensitivity,three-layer staining technique (e.g., including a biotinylated anti-mouse IgG (Cat. No. 405303) second step, followedby SAv-PE (Cat. No. 405204)).

Reinigung: The antibody was purified by affinity chromatography, and conjugated withAPC under optimal conditions. The solution is free of unconjugated APC andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-TSLPR (TSLP-R) antibody (APC)