CD274 Molecule (CD274) Antikörper (APC)

Antigen: CD274 Molecule (CD274)

Synonyme: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, CD274

Klonalität: Monoklonal (29E-2A3)

Wirt: Maus

Reaktivität: Human

Konjugat: APC

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN312050

Produktbeschreibung

Weitere Bezeichnung: CD274 (B7-H1, PD-L1)

Immunogen: full length human PD-L1

Isotyp: IgG2b, kappa chain

Klon: 29E-2A3

Beschreibung: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279(PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed forresponses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cellproliferation and IL-10 and IFN-g production in an IL-2-dependent and CD279-independent manner. Conflicting datahas shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cellactivation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for itsexpression in a wide variety of cell types including T and B cells, antigen-presenting cells, and nonhematopoieticcells.

Anwendungen

Reinigung: The antibody was purified by affinity chromatography, and conjugated withAPC under optimal conditions. The solution is free of unconjugated APC andunconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar