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Antikörper
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anti-Chemokine (C-C Motif) Receptor 3 (CCR3) Antikörper (APC)
Chemokine (C-C Motif) Receptor 3 (CCR3) Antikörper (APC)
| Antigen |
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| Synonyme |
CKR3, CD193, CMKBR3, CC-CKR-3, MGC102841 |
| Klonalität |
Monoklonal (5E8) |
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Wirt
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Reaktivität
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Konjugat
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Applikation
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| Produktnummer |
ABIN312040 |
| Menge |
100 tests (Varianten) |
| Preis |
324,29 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 5 bis 7 Werktagen |
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Weitere Bezeichnung
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CD193 (CCR3)
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Isotyp
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IgG2b, kappa chain
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Klon
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5E8
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Beschreibung
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CC-chemokine receptor 3 (CCR3), also known as CC CKR3, MIP1-alpha receptor like-2, eotaxin receptor, andCD193, is a member of G protein-coupled seven transmembrane receptors family. It binds to the CC chemokineseotaxin, eotaxin-2, eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes,platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play arole in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and -2, andthe binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.
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Applikationshinweise
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Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is 20 ul per million cells or 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performancefor each application. Additional reported applications (for the relevant formats) include: The 5E8 antibody is useful for immunofluorescentstaining and flow cytometric analysis of CCR3 expression.
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Reinigung
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The antibody was purified by affinity chromatography, and conjugated withAPC under optimal conditions. The solution is free of unconjugated APC andunconjugated antibody.
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Buffer
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Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).
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Lagerung
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The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Chemokine (C-C Motif) Receptor 3 (CCR3)", Typ "Antikörper" finden
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Wirte
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Kaninchen (20), Maus (4), Ziege (3), Ratte (2)
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Reaktivitäten
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Human (25), Maus (9), Ratte (Rattus) (4)
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Applikationen
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Western Blot (WB) (15), Immunhistochemie (Paraffinschnitte) (IHC (p)) (13), Enzyme Immunoassay (EIA) (7), Durchflusszytometrie (FACS) (7), Immunfluoreszenz (IF) (5), Immunhistochemie (IHC) (3), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (2), Dot Blot (Dot) (1), Neutralisierung (Neut) (1)
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Konjugate
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Alexa Fluor 647 (3), APC (1), PerCP,Cy5.5 (1)
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Epitope
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C-Term (3), N-Term (2)
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Alternativen 
