Chemokine (C-C Motif) Receptor 6 (CCR6) Antikörper (Alexa Fluor 647)

Antigen: Chemokine (C-C Motif) Receptor 6 (CCR6)

Synonyme: BN-1, CKR6, DCR2, CD196, CKRL3, DRY-6, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, GPR-CY4, CCR-6, KY411, Cmkbr6, CC-CKR-6, MGC108876, CCR6

Klonalität: Monoklonal (TG7-CCR6)

Wirt: Maus

Reaktivität: Human

Konjugat: Alexa Fluor 647

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN312014

Produktbeschreibung

Weitere Bezeichnung: CD196 (CCR6)

Immunogen: CCR6 transfectans

Isotyp: IgG2b, kappa chain

Klon: TG7-CCR6

Beschreibung: CCR6 is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells (1).CCR6 binds CCL20, although members of the beta defensin family also bind CCR6 with a lower affinity (2). CCR6positive cells and its ligand CCL20 have been detected in numerous organs, especially the secondary lymphoidorgan. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyer',s patches (PPs)and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to thesestructures (3). In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highlyexpressed on T cells resident in both normal and psoriatic skin (4), and CCR6 and/or CCL20 have been implicated inthe pathogenesis of rheumatoid arthritis (5) and inflammatory bowel disease. Human T cells that are able to produceIL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cellsto target tissues (6). Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal", mso-tstyle-rowband-size:0, mso-tstyle-colband-size:0, mso-style-noshow:yes,mso-style-priority:99, mso-style-qformat:yes, mso-style-parent:"", mso-padding-alt:0in 5.4pt 0in 5.4pt,mso-para-margin:0in, mso-para-margin-bottom:.0001pt, mso-pagination:widow-orphan, font-size:11.0pt,font-family:"Calibri","sans-serif", mso-ascii-font-family:Calibri, mso-ascii-theme-font:minor-latin,mso-fareast-font-family:"Times New Roman", mso-fareast-theme-font:minor-fareast, mso-hansi-font-family:Calibri,mso-hansi-theme-font:minor-latin, mso-bidi-font-family:"Times New Roman", mso-bidi-theme-font:minor-bidi,}

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor

Reinigung: The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor 647.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibody (Alexa Fluor 647)