IL-21 Antikörper (Alexa Fluor 647)

Antigen: IL-21

Klonalität: Monoklonal (3A3-N2)

Wirt: Maus

Reaktivität: Human

Konjugat: Alexa Fluor 647

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN311895

Produktbeschreibung

Immunogen: Recombinant full length human IL-21

Isotyp: IgG1, kappa chain

Klon: 3A3-N2

Beschreibung: Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularlythe inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. Theseactions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that candestroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendriticcells and can be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrinecytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target fortreating inflammatory diseases.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor

Reinigung: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor 647 under optimalconditions. The solution is free of unconjugated Alexa Fluor 647.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do notfreeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar