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Antikörper
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anti-Programmed Cell Death 1 (PDCD1) Antikörper (Alexa Fluor 647)
Programmed Cell Death 1 (PDCD1) Antikörper (Alexa Fluor 647)
| Antigen |
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| Synonyme |
PD1, CD279, SLEB2, hPD-1, hPD-l |
| Klonalität |
Monoklonal (EH12-2H7) |
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Wirt
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Reaktivität
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Konjugat
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Applikation
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Western Blot (WB) (38), Durchflusszytometrie (FACS) (34), Immunhistochemie (Paraffinschnitte) (IHC (p)) (19), Enzyme Immunoassay (EIA) (15), ELISA (12), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (8), Funktionale Studien (Func) (6), Immunhistochemie (IHC) (6), Immunfluoreszenz (IF) (4), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1)
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| Produktnummer |
ABIN311846 |
| Menge |
25 tests (Varianten) |
| Preis |
147,14 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 5 bis 7 Werktagen |
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Weitere Bezeichnung
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CD279 (PD-1)
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Isotyp
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IgG1, kappa chain
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Klon
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EH12-2H7
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Beschreibung
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The program death 1 (PD-1) receptor CD279, a 55 kDa member of the immunoglobulin superfamily. CD279/PD-1contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role inperipheral tolerance and autoimmune disease. CD279/PD-1 is expressed predominantly on activated T cells, B cellsand and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC)are ligands of CD279/PD-1 and are members of the B7gene family. Evidence reported to date suggests overlapping functions for these two PD-1 ligands and theirconstitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction ofCD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion.
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Applikationshinweise
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Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul ofwhole blood. It is recommended that the reagent be titrated for optimalperformance for each application.* Alexa Fluor
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Reinigung
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The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor 647 and unconjugated antibody.
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Buffer
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Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).
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Lagerung
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The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Programmed Cell Death 1 (PDCD1)", Typ "Antikörper" finden
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Wirte
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Maus (33), Kaninchen (22), Ratte (15), Ziege (6), Hamster (1)
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Reaktivitäten
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Human (61), Maus (31), Ratte (Rattus) (13), Hund (4)
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Applikationen
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Western Blot (WB) (38), Durchflusszytometrie (FACS) (34), Immunhistochemie (Paraffinschnitte) (IHC (p)) (19), Enzyme Immunoassay (EIA) (15), ELISA (12), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (8), Funktionale Studien (Func) (6), Immunhistochemie (IHC) (6), Immunfluoreszenz (IF) (4), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1)
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Konjugate
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FITC (7), PE (4), APC (2), PerCP,Cy5.5 (2), Alexa Fluor 647 (1), Pacific Blue (1), RPE (1)
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Epitope
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AA 21-167 (2), C-Term (1), Center (1)
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Alternativen 
