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GLE1 Antikörper (N-Term)

GLE1 Reaktivität: Human, Ratte, Maus, Pferd, Schwein, Kaninchen, Rind (Kuh), Saccharomyces cerevisiae, Hund, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN311714
  • Target Alle GLE1 Antikörper anzeigen
    GLE1 (GLE1 RNA Export Mediator (GLE1))
    Bindungsspezifität
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    Human, Ratte, Maus, Pferd, Schwein, Kaninchen, Rind (Kuh), Saccharomyces cerevisiae, Hund, Zebrafisch (Danio rerio)
    Wirt
    • 14
    • 3
    Kaninchen
    Klonalität
    • 16
    • 1
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    Dieser GLE1 Antikörper ist unkonjugiert
    Applikation
    • 12
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    LKLREAEQQR VKQAEQERLR KEEGQIRLRA LYALQEEMLQ LSQQLDASEQ
    Homologie
    Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 77%, Rat: 100%, Yeast: 90%, Zebrafish: 77%
    Produktmerkmale
    This is a rabbit polyclonal antibody against GLE1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human GLE1
    Top Product
    Discover our top product GLE1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 659 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GLE1 (GLE1 RNA Export Mediator (GLE1))
    Andere Bezeichnung
    GLE1 (GLE1 Produkte)
    Synonyme
    Dmel\\CG14749 antikoerper, GLE1 antikoerper, GLE1L antikoerper, LCCS antikoerper, LCCS1 antikoerper, hGLE1 antikoerper, Gle1l antikoerper, 4933405K21Rik antikoerper, AA553313 antikoerper, CG14749 gene product from transcript CG14749-RA antikoerper, nucleoporin GLE1 antikoerper, RNA export factor Gle1 antikoerper, GLE1, RNA export mediator antikoerper, GLE1 RNA export mediator antikoerper, GLE1 RNA export mediator (yeast) antikoerper, CG14749 antikoerper, CpipJ_CPIJ014147 antikoerper, SJAG_03847 antikoerper, GLE1 antikoerper, Gle1 antikoerper
    Hintergrund
    GLE1 is a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm.This gene encodes a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: GLE1L, hGLE1, LCCS, LCCS1
    Protein Interaction Partner: RNF2, UBC, ELAVL1, NUPL2, NUP155, EIF3F, UXT, KRT10,
    Protein Size: 659
    Molekulargewicht
    75 kDa
    Gen-ID
    2733
    NCBI Accession
    NM_001499, NP_001490
    UniProt
    Q53GS7
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