Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Antikörper

Antigen: Sodium Channel, Voltage-Gated, Type I, beta (SCN1B)

Synonyme: GEFSP1

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Rind (Kuh), Hund, Human, Maus, Kaninchen, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN309761

Produktbeschreibung

Weitere Bezeichnung: SCN1B

Beschreibung: Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM]. Keywords: SCN1B, GEFSP1, NP_001028

Anwendungen

Applikationshinweise: ELISA titre: 1:62500 . Western Blotting: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.

Forschungsgebiet: Signaltransduktion, Metabolismus

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) antibody

Publikationen

Publikationen: Selmer, Egeland, Solaas et al.: "Genetic screening of Scandinavian families with febrile seizures and epilepsy or GEFS+." in: Acta neurologica Scandinavica, Vol. 117, Issue 4, pp. 289-92, 2008 (PubMed).