GSTP1 Antikörper

Produktnummer ABIN1724656

Produktdetails anti-GSTP1 Antikörper

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSTP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human GSTP1 expressed in E. coli.

Klon: 3F2C2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-GSTP1 Antikörper (ABIN1724656)

Lin, Nelson: "Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells." in: Cancer research, Vol. 63, Issue 2, pp. 498-504, (2003) (PubMed).

Satoh, Itoh, Yamamoto, Tanaka, Hayakari, Ookawa, Yamazaki, Sato, Tsuchida, Hatayama: "Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells." in: Carcinogenesis, Vol. 23, Issue 3, pp. 457-62, (2002) (PubMed).

Details zu GSTP1

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Andere Bezeichnung: GSTP1 (GSTP1 Produkte)

Synonyme: DFN7 antikoerper, FAEES3 antikoerper, GST3 antikoerper, GSTP antikoerper, PI antikoerper, GST-P antikoerper, Gst3 antikoerper, Gstp antikoerper, Gstp2 antikoerper, gst-Pi antikoerper, GstpiB antikoerper, glutathione S-transferase P-like antikoerper, glutathione S-transferase pi 1 antikoerper, glutathione S-transferase pi 1 L homeolog antikoerper, glutathione S-transferase, pi 1 antikoerper, LOC100739163 antikoerper, GSTP1 antikoerper, Gstp1 antikoerper, LOC100861197 antikoerper, gstp1.L antikoerper

Hintergrund:

Description: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90 % ) of prostate carcinomas and is associated with transcriptional down-regulation.

Aliases: PI, DFN7, GST3, FAEES3

Molekulargewicht: 23 kDa

Gen-ID: 2950

HGNC: 2950

Pathways: Cellular Response to Molecule of Bacterial Origin