Vav 3 Oncogene (VAV3) (pY173) Antikörper

Antigen: Vav 3 Oncogene (VAV3)

Synonyme: FLJ40431, AA986410, MGC27838, A530094I06Rik, RGD1565941, VAV3, LOC100220994

Epitope: pY173

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN307104

Produktbeschreibung

Weitere Bezeichnung: phospho Vav3 [pY173]

Swiss-Prot: Q9UKW4

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Vav proteins belong to the guanidine nucleotide exchange factor family of proteins. These proteins couple receptors to Rho-GTPases. To date, three members of the Vav family have been identified in mammalian cells: Vav1, Vav2, and Vav3. Vav proteins contain multiple protein binding motifs and act as adaptor proteins linking cell surface receptors to downstream signaling proteins. Vav3 transcripts are ubiquitously expressed in wide variety of cell lines including hematopoietic cells, suggesting its role in lymphocyte development and antigen receptor mediated activation of NFAT and NF B. Vav3 is also involved in activating JNK, p21-activated kinase (PAK) and PLC , implicating a critical role in cytoskeletal rearrangement. Vav3 is inducibly tyrosine phosphorylated in response to stimulation of the epidermal growth factor (EGFR), platelet-derived growth factor (PDGFR) and T-cell receptors (TCR), enhancing its guanine nucleotide exchange factor activity in vitro. Tyrosine 173 is the regulatory phosphorylation site of Vav3.

Anwendungen

Applikationshinweise: Antibody can be used for Western blotting (1:1000 dilution). Positive Control: Cos7 cells overexpressing Vav3, +/- epidermal growth factor (EGF).

Lagerung: Product should be stored at -70C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar