Vav 1 Oncogene (VAV1) (pY160) Antikörper

Antigen: Vav 1 Oncogene (VAV1)

Synonyme: VAV, Vav, vav-T, vav1, MGC80607, VAV1

Epitope: pY160

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN307103

Produktbeschreibung

Weitere Bezeichnung: phospho Vav1 [pY160]

Swiss-Prot: P15498

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Vav proteins belong to the guanidine nucleotide exchange factor family of proteins. These proteins couple receptors to Rho-GTPases. To date, three members of the Vav family have been identified in mammalian cells: Vav1, Vav2, and Vav3. Vav1 contains multiple protein binding motifs, indicating a role for Vav1 as an adaptor protein linking cell surface receptors to downstream signaling proteins. Vav1 is exclusively expressed in hematopoietic cells and plays a significant role in lymphocyte development and antigen receptor mediated activation of NFAT and NF B, and in more delayed responses such as the production of cytokines, including IL-2, IL-3, IFN- and TNF- . Vav1 is also reported to activate JNK, p21-activated kinase (PAK) and PLC , implicating its critical role in calcium mobilization, and cytoskeletal rearrangement. Activation of several cell surface receptors including integrins, immune response receptors, or growth factor receptors leads to phosphorylation of Vav1 on tyrosine residues including tyrosine 160.

Anwendungen

Applikationshinweise: Antibody can be used for Western blotting (1:1000 dilution). Positive Control: K562 cells expressing wild-type Intergrin v and 3 proteins..

Lagerung: Product should be stored at -70C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar