Amyloid beta (Abeta) (AA 1-16) Antikörper

Antigen: Amyloid beta (Abeta)

Synonyme: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma, APP

Epitope: AA 1-16

Klonalität: Monoklonal (6-00E-10)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN307037

Produktbeschreibung

Weitere Bezeichnung: beta-Amyloid (Abeta) [1-16]

Swiss-Prot: P05067

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 6-00E-10

Beschreibung: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. They bind transient metals such as copper, zinc and iron. and in vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.1 The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosisSynonyms: APP.

Anwendungen

Applikationshinweise: The antibody has been used in the immunohistochemical detection of A in fixed sections of Alzheimer

Konzentration: 1 mg/ml

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar