beta-Site APP-Cleaving Enzyme 1 (BACE) (C-Term) Antikörper

Antigen: beta-Site APP-Cleaving Enzyme 1 (BACE)

Synonyme: ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN306765

Produktbeschreibung

Weitere Bezeichnung: Beta-secretase 1 (CT)

Swiss-Prot: P56817

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Accumulation of the amyloid- (A ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A peptide is generated by proteolytic cleavage of the amyloid protein precursor (APP) at - and -sites by two proteases. APP is first cleaved by secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for secretase to generate the 4 kDa amyloid- peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. Synonyms: BACE, KIAA1149, Beta-site amyloid precursor protein cleaving enzyme 1.

Synonyme: ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2

Anwendungen

Applikationshinweise: Detects BACE by Western blot at 0.5 to 1 ug/ml. Detects an approximately 70 kDa band in human brain tissue lysate. Positive Control: Human brain tissue lysate.

Konzentration: 0.5 mg/ml

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar