serine/threonine Kinase 17a (STK17A) (N-Term) Antikörper

Antigen: serine/threonine Kinase 17a (STK17A)

Synonyme: DAP6, EAP1, BING2, MGC126245, MGC126246, MGC150289, DAP-3, 4921514D13Rik, im:6905684, LOC100226911, DRAK1, STK17A, MGC140096

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN306755

Produktbeschreibung

Weitere Bezeichnung: Serine/threonine-protein kinase 17A (NT), DRAK1 (NT)

Swiss-Prot: Q9UEE5

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases1. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues1. Synonyms: DAPK Related Apoptosis inducing Kinase 1, N-Terminal, STK17A.

Anwendungen

Applikationshinweise: Detects DRAK1 by Western blot at 0.5 to 1 ug/ml. Detects an approximately 50 kDa band in MOLT4, A431 and 3T3 whole cell lysates. Does not cross react with DRAK2, DAP or ZIP kinases. Positive Control: MOLT4 or A431 whole cell lysates.

Konzentration: 0.5 mg/ml

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar