BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (internal) Antikörper

Antigen: BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L)

Synonyme: NIX, BNIP3a, Nix

Epitope: internal

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN306750

Produktbeschreibung

Weitere Bezeichnung: Bnip3L (IN) (nix) (bcl 2 family)

Swiss-Prot: O60238

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3 , and Nix (for Nip3-like protein X) (1-3). Bnip3L/Bnip3 /Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (2,3). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (1,2). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins. Synonyms: BNIP3A, BNIP3H, NIX.

Anwendungen

Applikationshinweise: Detects Bnip3L by Western blot at 0.5 to 1 ug/ml. Detects a 40 kDa band in K562 cell lysate which represents the monomer of Bnip3L. Positive Control: K562 cell lysate.

Konzentration: 0.5 mg/ml

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar