B-Cell CLL/lymphoma 10 (BCL10) (N-Term) Antikörper

Antigen: B-Cell CLL/lymphoma 10 (BCL10)

Synonyme: CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10, MGC108338

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN306749

Produktbeschreibung

Weitere Bezeichnung: bcl 10 (NT) (CipER, CLAP)

Swiss-Prot: O95999

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6). Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF- B activation (1,2,4,6). Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation (3.6). BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy (1,5). BCL10 is expressed in many human and murine tissues and cell lines (2-6). Synonyms: CIPER, mE10, CARMEN, CLAP.

Anwendungen

Applikationshinweise: Detects BCL10 by Western blot at 1 ug/ml. Detects a 31 kDa band in Raji whole cell lysate. Positive Control: Raji whole cell lysate.

Konzentration: 0.5 mg/ml

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar