Tetanus Toxin (TetX) Antikörper

Antigen: Tetanus Toxin (TetX)

Klonalität: Monoklonal (TetH6)

Wirt: Maus

Reaktivität: Bakterien

Applikation: Western Blot (WB), ELISA, Funktionale Studien (Func)

Produktnummer: ABIN305125

Produktbeschreibung

Weitere Bezeichnung: Tetanus Toxin

Immunogen: Supernatant from Clostridium tetani.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: TetH6

Beschreibung: Gene: Tetanus Toxin, Standard Gene Symbol: TT, Synonyms: , TT

Spezifität: Recognizes the tetanus toxin, a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterized by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300000 to 500000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kD and consists of a heavy chain (B-chain, 100kD) and a light chain (A-chain, 50kD) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible. Has toxin neutralizing activity. Removal of sodium azide is recommended prior to use in functional assays.

Anwendungen

Applikationshinweise: ELISA, Func, WB

Konzentration: 1 mg/ml

Reinigung: Affinity Chromatography

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Lagerung: +4°C or -20°C, Avoid repeated freezing and thawing.

Forschungsgebiet: Neurologie

Beschränkungen: Nur für Forschungszwecke einsetzbar